{"id":14781,"date":"2025-09-21T17:00:00","date_gmt":"2025-09-21T15:00:00","guid":{"rendered":"https:\/\/holistic.news\/en\/?p=14781"},"modified":"2026-02-21T08:58:26","modified_gmt":"2026-02-21T07:58:26","slug":"viruses-in-our-dna","status":"publish","type":"post","link":"https:\/\/holistic.news\/en\/viruses-in-our-dna\/","title":{"rendered":"Viruses in our DNA: can we switch them off?"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-viruses-in-our-dna-the-phenomenon-behind-the-hype\">Viruses in our DNA \u2014 the phenomenon behind the hype<\/h2>\n\n\n\n<p>Our genomes carry vast traces of ancient infections. Researchers estimate <strong>40 percent of human DNA comes from long-dead viruses<\/strong>. Most of these elements are retrotransposons \u2014 \u201cjumping genes\u201d that copy and paste themselves into new spots on chromosomes. For years, scientists dismissed them as harmless \u201cjunk DNA.\u201d However, new findings force a rethink. Do viruses in our DNA pose a threat?<\/p>\n\n\n\n<p>In 2008, neurologist Ren\u00e9e Douville observed something striking in the brains of people who had died of amyotrophic lateral sclerosis (ALS): viral proteins. Yet those patients had no active viral infection. <strong>Where did the proteins come from? The best explanation is that retrotransposons had awakened and begun to replicate.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-why-they-wake-and-what-follows\">Why they wake \u2014 and what follows<\/h2>\n\n\n\n<p>Evidence keeps mounting that these hidden virus-genes may underlie some cases of neurodegenerative disease, including ALS and Alzheimer\u2019s. What brings them back to life? Most likely aging and associated cellular stress. Normally, our cells lock these elements down, packing them tightly into specific DNA regions. <strong>With age, though, those \u201cdoors\u201d can crack open, letting retrotransposons slip free<\/strong>.<\/p>\n\n\n\n<p>When the virus-genes wake, a \u201cretrotransposon storm\u201d can follow \u2014 a term scientist Josh Dubnau coined after studies in fruit flies and mice. His work shows that <strong>activating jumping genes in brain cells can prompt those cells to kill their neighbors, driving neurodegeneration<\/strong>. Worse, a vicious cycle forms: retrotransposon activation disrupts key proteins \u2014 such as TDP-43 in ALS or tau in Alzheimer\u2019s \u2014 and those protein malfunctions, in turn, fuel further activation of the virus-genes.<\/p>\n\n\n\n<p><strong>Read also:<\/strong> <a href=\"https:\/\/holistic.news\/en\/prehistoric-zombie-fungus-extraordinary-amber-discovery\/\" target=\"_blank\" rel=\"noreferrer noopener\">100 Million Years in a Deadly Trap: How Zombie Fungi Operate<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-viruses-in-dna-can-be-disarmed-a-path-to-treatment\">Viruses in DNA can be disarmed \u2014 a path to treatment<\/h2>\n\n\n\n<p>If retrotransposons behave like viruses, can antivirals stop them? Researchers asked exactly that \u2014 and early answers look promising. <strong>Antiretroviral drugs used against HIV block an enzyme critical for retrotransposon replication<\/strong>.<\/p>\n\n\n\n<p>In mice, fruit flies, and cell models, these medicines suppress jumping-gene activity and reduce neurodegeneration. <strong>Human studies, while still limited, add cautious hope<\/strong>. As reported in <em><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21678421.2019.1632899\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration<\/a><\/em>, patients with ALS who received anti\u2013virus-gene drugs showed a slower disease course. Similarly, a small trial in early Alzheimer\u2019s found the approach safe (published in <em><a href=\"https:\/\/www.nature.com\/articles\/s44400-024-00001-z\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">npj Dementia<\/a><\/em>).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-comes-next\">What comes next<\/h2>\n\n\n\n<p>Scientists are now widening the lens to explore links with Parkinson\u2019s disease, multiple sclerosis, and other conditions. For now, drug candidates that target <strong>viruses in our DNA <\/strong>remain in clinical testing. <strong>How many disorders trace back to these genomic stowaways<\/strong> \u2014 and can we switch them off without serious side effects? The next few years should bring the answers.<\/p>\n\n\n\n<p><strong>Last take-away<\/strong>:<br>Bottom line: evidence is building that viruses in our DNA <a href=\"https:\/\/holistic.news\/en\/dragon-hole-unknown-viruses-1700-new-strains\/\">can awaken<\/a>, damage brain tissue, and \u2014 crucially \u2014 might be tamed by targeted antivirals.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><em>Read the original article:<\/em> <a href=\"https:\/\/holistic.news\/wirusy-w-dna-czaja-sie-tam-od-milionow-lat-jak-sie-ich-pozbyc\/\" target=\"_blank\" rel=\"noreferrer noopener\">A\u017c&nbsp;40 proc. Twojego&nbsp;DNA to&nbsp;wirusy. Co&nbsp;si\u0119 stanie, je\u015bli si\u0119 obudz\u0105?<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dormant viral fragments hide in every human genome. They can wake \u2014 and strike. It\u2019s not sci-fi but a live hypothesis for some diseases. Scientists now probe how \u201cjumping genes\u201d shape the brain \u2014 and whether viruses in our DNA can be safely silenced.<\/p>\n","protected":false},"author":275,"featured_media":14782,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[435],"tags":[1807,1661,1439,1179,1399,1808,1806],"class_list":["post-14781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-als","tag-brain-health","tag-dna","tag-health","tag-medicine","tag-neurodegeneration","tag-viruses-in-our-dna"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Viruses in our DNA: can we switch them off?<\/title>\n<meta name=\"description\" content=\"Do viruses in our DNA threaten brain health? New research ties \u201cjumping genes\u201d to neurodegeneration \u2014 and tests drugs that might stop them.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/holistic.news\/en\/viruses-in-our-dna\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Viruses in our DNA: can we switch them off?\" \/>\n<meta property=\"og:description\" content=\"Do viruses in our DNA threaten brain health? New research ties \u201cjumping genes\u201d to neurodegeneration \u2014 and tests drugs that might stop them.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/holistic.news\/en\/viruses-in-our-dna\/\" \/>\n<meta property=\"og:site_name\" content=\"Holistic News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/portalHolisticNews\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-21T15:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-21T07:58:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/holistic.news\/en\/wp-content\/uploads\/2025\/09\/Viruses-in-our-DNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Maciej Bartusik\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@news_holistic\" \/>\n<meta name=\"twitter:site\" content=\"@news_holistic\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maciej Bartusik\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/\"},\"author\":{\"name\":\"Maciej Bartusik\",\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/#\\\/schema\\\/person\\\/0758fb0cf338b71ce51e2da415bc266c\"},\"headline\":\"Viruses in our DNA: can we switch them off?\",\"datePublished\":\"2025-09-21T15:00:00+00:00\",\"dateModified\":\"2026-02-21T07:58:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/\"},\"wordCount\":485,\"publisher\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/holistic.news\\\/en\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Viruses-in-our-DNA.jpg\",\"keywords\":[\"ALS\",\"brain health\",\"DNA\",\"health\",\"medicine\",\"neurodegeneration\",\"viruses in our dna\"],\"articleSection\":[\"Science\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/\",\"url\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/\",\"name\":\"Viruses in our DNA: can we switch them off?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/holistic.news\\\/en\\\/viruses-in-our-dna\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/holistic.news\\\/en\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Viruses-in-our-DNA.jpg\",\"datePublished\":\"2025-09-21T15:00:00+00:00\",\"dateModified\":\"2026-02-21T07:58:26+00:00\",\"description\":\"Do viruses in our DNA threaten brain health? 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