{"id":14845,"date":"2025-09-29T08:00:00","date_gmt":"2025-09-29T06:00:00","guid":{"rendered":"https:\/\/holistic.news\/en\/?p=14845"},"modified":"2025-12-05T20:31:19","modified_gmt":"2025-12-05T19:31:19","slug":"preventing-cancer-recurrence","status":"publish","type":"post","link":"https:\/\/holistic.news\/en\/preventing-cancer-recurrence\/","title":{"rendered":"Preventing cancer recurrence. A big step forward"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">A sleeping enemy you can\u2019t detect<\/h2>\n\n\n\n<p>Breast cancer is the second most commonly diagnosed cancer in women. No wonder clinicians keep searching for better ways to detect and treat it. Scientists in the United States have taken an important step: they managed to prevent the disease from coming back. Why does relapse happen?<\/p>\n\n\n\n<p>In many people who have beaten cancer, so-called <strong>dormant cancer cells<\/strong> can remain in the body. Current imaging tests can\u2019t detect them. These cells may \u201cwake up\u201d over time, trigger a recurrence, and even lead to metastases. The problem is, you can\u2019t predict when \u2014 it might be years later, or even longer.<\/p>\n\n\n\n<p>It now turns out that to destroy dormant <a href=\"https:\/\/holistic.news\/en\/new-breast-cancer-treatment-scorpion-toxin-breakthrough\/\">cancer cells<\/a>, it may be enough to give patients <strong>drugs already in use<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">They achieved 100 percent effectiveness<\/h2>\n\n\n\n<p>The researchers studied <strong>51<\/strong> women who had beaten breast cancer within the past <strong>5<\/strong> years. Participants were divided into <strong>three<\/strong> groups: one took <strong>hydroxychloroquine<\/strong>, another <strong>everolimus<\/strong>, and the third took <strong>both drugs<\/strong> together. All of these medicines are already approved for medical use.<\/p>\n\n\n\n<p>After <strong>3.5<\/strong> years of follow-up \u2014 results published in <em><a href=\"https:\/\/www.nature.com\/articles\/s41591-025-03877-3\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Nature Medicine<\/a><\/em> \u2014 the team reported promising outcomes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>91.7 percent<\/strong> of women taking hydroxychloroquine had <strong>no recurrence<\/strong>;<\/li>\n\n\n\n<li><strong>92.9 percent<\/strong> of women taking everolimus also remained cancer-free;<\/li>\n\n\n\n<li><strong>100 percent of women taking both drugs had no relapse.<\/strong><\/li>\n<\/ul>\n\n\n\n<p>The results are welcome news for women worried about the return of cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why these drugs work \u2014 and preventing cancer recurrence<\/h2>\n\n\n\n<p>Before using the drugs in the study, the team tested them successfully in mice to better understand how they work. It turned out both medicines bolster <strong>two key processes<\/strong> that can help stave off relapse: <strong>autophagy<\/strong> and the <strong>mTOR signaling pathway<\/strong>.<\/p>\n\n\n\n<p><strong>Read how<\/strong>: <a href=\"https:\/\/holistic.news\/en\/a-simple-blood-test-to-treat-childhood-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">Polish scientists will help children with cancer<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Preventing relapse could get simpler<\/h2>\n\n\n\n<p>The findings could mark a breakthrough in modern medicine: with these two drugs, <strong>preventing cancer recurrence<\/strong> in breast cancer may become much simpler.<\/p>\n\n\n\n<p><em>\u201cThe uncertainty about whether cancer will come back hangs over many people after treatment ends. Right now, we can\u2019t predict if or when it will return \u2014 and that\u2019s the problem we set out to solve. Our study shows that monitoring and targeting dormant cancer cells is a strategy with real potential. I hope it spurs further research,\u201d<\/em> said Dr. Angela DeMichele, professor at the Breast Care Center of Excellence at Penn Medicine.<\/p>\n\n\n\n<p>If these results hold up in larger trials, they could move us closer to routine strategies for preventing cancer recurrence.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><em>Read this article in Polish<\/em>: <a href=\"https:\/\/holistic.news\/zapobieganie-nawrotom-raka\/\" target=\"_blank\" rel=\"noreferrer noopener\">Wa\u017cny krok w&nbsp;walce z&nbsp;rakiem. Nowotw\u00f3r nie&nbsp;wr\u00f3ci\u0142<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Breast cancer relapse is a nightmare millions of women face. Researchers at the University of Pennsylvania, led by Dr. Angela DeMichele, now show that preventing cancer recurrence can be 100 percent effective. The biggest surprise? They didn\u2019t use new drugs.<\/p>\n","protected":false},"author":274,"featured_media":14850,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[435],"tags":[1849,1406,1850,1179,1399,1851,1848,834],"class_list":["post-14845","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-breast-cancer","tag-cancer","tag-combination-therapy","tag-health","tag-medicine","tag-oncology-research","tag-preventing-cancer-recurrence","tag-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Preventing cancer recurrence. A big step forward<\/title>\n<meta name=\"description\" content=\"Breakthrough from Penn: preventing cancer recurrence without new drugs. 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